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Prednisone is inactive in the body. Prednisolone is a corticosteroid used to treat various inflammatory and allergy conditions as well as other diseases. Prednisone is the most commonly-prescribed oral corticosteroid. Prednisone is used as replacement therapy in patients whose adrenal glands are unable to produce sufficient amounts of cortical. In much higher doses than the levels of corticosteroids produced naturally by the body. Steroid medication needs may change if you have any of these conditions, you may need a dose adjustment or special tests to safely take Prednisolone.